Endocrine Abstracts

Moderately elevated body iron stores may be associated with several components of the metabolic syndrome (MetSyn). Elevated serum ferritin levels (Fer) independently predicted incident type 2 diabetes in prospective studies in apparently healthy men and women.Aims: To analyze the association between Fer and components of MetSyn in transsexuals before and after 2-year cross-sex treatment (CST).Methods: Before starting the CST in 90 ...

Various risk factors act synergistically for the development of micro and macrovascular complications in type 2 diabetes mellitus (T2DM) patients. The contributions of risk factors have yet to be clearly identified and quantified, but diabetic dyslipidaemia has specific importance.Objective: To investigate the association of dyslipidaemia with micro and macrovascular complications in a T2DM population.Materials and methods: Cross s...

Elevated serum ferritin levels has been reported in premenopausal women presenting polycystic ovary syndrome (PCOS) and hyperandrogenism, and thus may be involved in the development of insulin resistance, type 2 diabetes y cardiovascular disease. In female-to-male transsexuals (FMTs) PCOS is frequent and this issue has been little studied.Aims: To study the serum ferritin in FMTs with PCOS and their relations with markers of insulin resistance (IR) and m...

Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties, and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly data on adiponectin are contradictory and there are no data on visfatin.Objectives: To evaluate adiponectin and visfatin in acromegaly, compared to control subjects and to analyze their relationship with body composition and bone mineral mar...

Background: Classic 21-hydroxylase deficiency, due to severe mutations in CYP21B gene, is an uncommon disease (1/ 150 000). Salt-wasting form accounts for 75% of the cases and turns up with gluco- and mineralocorticoid deficiency as well as feminine hermaphroditism. Although wide psycho-social repercussion especially in women is known, the rarity of the disease and losses in follow-up may lead to a scarce clinical experience. We present 3 adult patients with CAH- SW followed r...

Despite advances in the management of last years, diabetes and its complications are still the most frequent cause of admission in Endocrine Departments. Nowadays, in our Hospital, 60% of admissions are due to Diabetes, and more than a half of these are diabetic ketoacidosis (DKA) (35.4%).Objective: Analize DKA episodes in our medical area in the last 12 years and compare them divided in two periods.Methods: Divide DKA episodes in ...

Acromegaly is associated with increased morbidity and mortality. Surgery, radiotherapy (RT) and medical therapy are the treatment options to decrease GH and IGF-I concentrations to levels associated with cure or normalisation of mortality. We examined the response to dopamine agonists (DA) and somatostatin analogues (SSA) in 276 patients with acromegaly who received medical therapy during follow up (198 DA, 143 SSA). One hundred and seventy two had surgery and 73 RT prior to m...

Acromegaly is associated with increased morbidity and mortality. There are several treatment options for acromegaly including surgery, radiotherapy and medical therapy. The aims of treatment in patients with acromegaly is to achieve GH and IGF-I concentrations associated with cure or normalisation of mortality.We examined predictive factors of response to treatment with dopamine agonists (DA) and somatostatin analogues (SSA) in a cohort of 501 patients w...

Introduction: Post-stroke hyperglycemia affects two-thirds of the patients during acute ischaemic stroke and it is associated with poorer outcomes. The aim of this study was to analyze the differences between the diabetic and non- diabetic patients that underwent an acute stroke.Methods: Retrospective descriptive study of patients admitted to the Acute Stroke Unit from January to June 2017, including blood parameters, glycemic treatment and 3 months outc...

Objetives: To analyze the profile of patients referred from Primary Care (PC) to Outpatient Diabetes Center (ODC), as well as the evolution of self-assessment measured by Chronic Care Model IEMAC (Instrument for the Evaluation of Attention Chronicity Models) tool after implementation of a coordinated Task Force between Primary Care and Endocrinology Unit.Methods: The working group of the Advanced Diabetes Center in Cádiz-San Fernando Sanitary Area w...